Natural Occurring Polymorphisms in HIV-1 Integrase and RNase H Regulate Viral Release and Autoprocessing.

Imamichi, Tomozumi; Bernbaum, John G; Laverdure, Sylvain; Yang, Jun; Chen, Qian; Highbarger, Helene; Hao, Ming; Sui, Hongyan; Dewar, Robin; Chang, Weizhong; Lane, H Clifford

Imamichi, Tomozumi; Bernbaum, John G; Laverdure, Sylvain; Yang, Jun; Chen, Qian; Highbarger, Helene; Hao, Ming; Sui, Hongyan; Dewar, Robin; Chang, Weizhong; Lane, H Clifford.

Afiliação

Imamichi T; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Developmental Directorate, Frederick National Laboratory, Frederick, Maryland, USA.
Bernbaum JG; Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, USA.
Laverdure S; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Developmental Directorate, Frederick National Laboratory, Frederick, Maryland, USA.
Yang J; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Developmental Directorate, Frederick National Laboratory, Frederick, Maryland, USA.
Chen Q; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Developmental Directorate, Frederick National Laboratory, Frederick, Maryland, USA.
Highbarger H; Virus Isolation and Serology Laboratory, Applied and Developmental Directorate, Frederick National Laboratory, Frederick, Maryland, USA.
Hao M; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Developmental Directorate, Frederick National Laboratory, Frederick, Maryland, USA.
Sui H; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Developmental Directorate, Frederick National Laboratory, Frederick, Maryland, USA.
Dewar R; Virus Isolation and Serology Laboratory, Applied and Developmental Directorate, Frederick National Laboratory, Frederick, Maryland, USA.
Chang W; Laboratory of Human Retrovirology and Immunoinformatics, Applied and Developmental Directorate, Frederick National Laboratory, Frederick, Maryland, USA.
Lane HC; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

J Virol ; 95(23): e0132321, 2021 11 09.

Article em En | MEDLINE | ID: mdl-34523971

Assuntos

Integrase de HIV/metabolismo; HIV-1/fisiologia; Ribonuclease H/metabolismo; Liberação de Vírus/fisiologia; Antirretrovirais/farmacologia; Produtos do Gene gag/genética; Células HEK293; Infecções por HIV; Integrase de HIV/genética; HIV-1/genética; Humanos; Mutação; Polimorfismo de Nucleotídeo Único; Proteólise; Ribonuclease H/genética; Vírion/metabolismo; Replicação Viral

Palavras-chave

RNase H; SNPs; autoprocessing; human immunodeficiency virus; integrase

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: HIV-1 / Ribonuclease H / Integrase de HIV / Liberação de Vírus Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google