Characterization of the m6A-Associated Tumor Immune Microenvironment in Prostate Cancer to Aid Immunotherapy.

Liu, Zezhen; Zhong, Jiehui; Zeng, Jie; Duan, Xiaolu; Lu, Jianming; Sun, Xinyuan; Liu, Qinwei; Liang, Yingke; Lin, Zhuoyuan; Zhong, Weide; Wu, Wenzheng; Cai, Chao; Zeng, Guohua

Liu, Zezhen; Zhong, Jiehui; Zeng, Jie; Duan, Xiaolu; Lu, Jianming; Sun, Xinyuan; Liu, Qinwei; Liang, Yingke; Lin, Zhuoyuan; Zhong, Weide; Wu, Wenzheng; Cai, Chao; Zeng, Guohua.

Afiliação

Liu Z; Department of Urology, Minimally Invasive Surgery Center, Guangdong Key Laboratory of Urology, Guangzhou Urology Research Institute, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Zhong J; Department of Urology, Minimally Invasive Surgery Center, Guangdong Key Laboratory of Urology, Guangzhou Urology Research Institute, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Zeng J; Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Duan X; Department of Urology, Minimally Invasive Surgery Center, Guangdong Key Laboratory of Urology, Guangzhou Urology Research Institute, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Lu J; Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Sun X; Department of Urology, Minimally Invasive Surgery Center, Guangdong Key Laboratory of Urology, Guangzhou Urology Research Institute, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Liu Q; Department of Urology, Minimally Invasive Surgery Center, Guangdong Key Laboratory of Urology, Guangzhou Urology Research Institute, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Liang Y; Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Lin Z; Department of Urology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Zhong W; Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Wu W; Department of Urology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Cai C; Department of Urology, Minimally Invasive Surgery Center, Guangdong Key Laboratory of Urology, Guangzhou Urology Research Institute, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Zeng G; Department of Urology, Minimally Invasive Surgery Center, Guangdong Key Laboratory of Urology, Guangzhou Urology Research Institute, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.

Front Immunol ; 12: 735170, 2021.

Article em En | MEDLINE | ID: mdl-34531875

Assuntos

Adenosina/análogos & derivados; Biomarcadores Tumorais/metabolismo; Neoplasias da Próstata/metabolismo; Processamento Pós-Transcricional do RNA; Microambiente Tumoral; Adenosina/genética; Adenosina/metabolismo; Biomarcadores Tumorais/genética; Tomada de Decisão Clínica; Bases de Dados Genéticas; Perfilação da Expressão Gênica; Regulação Neoplásica da Expressão Gênica; Ribonucleoproteínas Nucleares Heterogêneas Grupo A-B/genética; Ribonucleoproteínas Nucleares Heterogêneas Grupo A-B/metabolismo; Humanos; Inibidores de Checkpoint Imunológico/uso terapêutico; Imunoterapia; Linfócitos do Interstício Tumoral/imunologia; Linfócitos do Interstício Tumoral/metabolismo; Masculino; Metiltransferases/genética; Metiltransferases/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Neoplasias da Próstata/tratamento farmacológico; Neoplasias da Próstata/genética; Neoplasias da Próstata/imunologia; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Linfócitos T Auxiliares-Indutores/imunologia; Linfócitos T Auxiliares-Indutores/metabolismo; Transcriptoma; Macrófagos Associados a Tumor/imunologia; Macrófagos Associados a Tumor/metabolismo

Palavras-chave

Immunotherapy; PCa; Tumor Immune Microenvironment; m6A; prognosis

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Biomarcadores Tumorais / Adenosina / Processamento Pós-Transcricional do RNA / Microambiente Tumoral Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Front Immunol Ano de publicação: 2021 Tipo de documento: Article

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