Efficient synthesis of α,ß-dichlorinated ketones from α,ß-dichlorinated Weinreb amides through a simple work-up procedure.
Org Biomol Chem
; 19(36): 7822-7826, 2021 09 22.
Article
em En
| MEDLINE
| ID: mdl-34549216
An efficient synthesis of α,ß-dichlorinated ketones from α,ß-dichlorinated Weinreb amides is described. Quenching with nonaqueous HCl avoided side reactions associated with typical work-up procedures. The amide reacted with various nucleophiles to give the corresponding ketones in high yields. A novel reactivity of the Weinreb amide is also discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Ano de publicação:
2021
Tipo de documento:
Article