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Efficient synthesis of α,ß-dichlorinated ketones from α,ß-dichlorinated Weinreb amides through a simple work-up procedure.
Prakoso, Nurcahyo Iman; Matsuda, Fuyuhiko; Umezawa, Taiki.
Afiliação
  • Prakoso NI; Division of Environmental Materials Science, Graduate School of Environmental Science, Hokkaido University, N10W5 Sapporo 060-0810, Japan. umezawa@ees.hokudai.ac.jp.
  • Matsuda F; Chemistry Department, Universitas Islam Indonesia, Sleman, Yogyakarta, Indonesia.
  • Umezawa T; Division of Environmental Materials Science, Graduate School of Environmental Science, Hokkaido University, N10W5 Sapporo 060-0810, Japan. umezawa@ees.hokudai.ac.jp.
Org Biomol Chem ; 19(36): 7822-7826, 2021 09 22.
Article em En | MEDLINE | ID: mdl-34549216
An efficient synthesis of α,ß-dichlorinated ketones from α,ß-dichlorinated Weinreb amides is described. Quenching with nonaqueous HCl avoided side reactions associated with typical work-up procedures. The amide reacted with various nucleophiles to give the corresponding ketones in high yields. A novel reactivity of the Weinreb amide is also discussed.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Ano de publicação: 2021 Tipo de documento: Article