Synthesis of the Bridged [5-7-7] Tricyclic Core of Eurifoloid A.
Org Lett
; 23(20): 7771-7775, 2021 10 15.
Article
em En
| MEDLINE
| ID: mdl-34554764
ABSTRACT
We herein describe a new approach for the efficient and asymmetric construction of the tricyclic core of eurifoloid A, which possesses a unique and highly strained bicyclo[4.4.1] ring system. A rhodium-catalyzed intramolecular [3 + 2] dipolar cycloaddition was developed to install synthetically challenging bridged bicyclo[4.3.1] ring systems. The reported chemistry shows the feasibility of constructing the eurifoloid A framework using a diastereoselective intramolecular [3 + 2] cycloaddition and a ring enlargement.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Bicíclicos com Pontes
/
Diterpenos
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2021
Tipo de documento:
Article