Enhanced GRP78 protein expression via the IRE1&#945;/ASK1/p38 MAPK pathway during As<sub>2</sub>O<sub>3</sub>-induced endoplasmic reticulum stress in BEAS-2B cells.

Yuan, Jiaming; Yao, Chenjuan; Tang, Jing; Liu, Yingqi; Huang, Chunyan; Yu, Shali; Wei, Haiyan; Han, Yu; Chen, Gang

Enhanced GRP78 protein expression via the IRE1α/ASK1/p38 MAPK pathway during As₂O₃-induced endoplasmic reticulum stress in BEAS-2B cells.

Yuan, Jiaming; Yao, Chenjuan; Tang, Jing; Liu, Yingqi; Huang, Chunyan; Yu, Shali; Wei, Haiyan; Han, Yu; Chen, Gang.

Afiliação

Yuan J; Department of Occupational Medicine and Environmental Toxicology, College of Public Health, Nantong University, Nantong, Jiangsu, 226019, China.
Yao C; Department of Molecular Oral Physiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima-Shi, Tokushima, 770-8504, Japan.
Tang J; Department of Occupational Medicine and Environmental Toxicology, College of Public Health, Nantong University, Nantong, Jiangsu, 226019, China.
Liu Y; Department of Occupational Medicine and Environmental Toxicology, College of Public Health, Nantong University, Nantong, Jiangsu, 226019, China; Wujiang Center for Disease Control and Prevention, Suzhou, 215299, China.
Huang C; Department of Chronic Disease Prevention and Control, Suzhou Center for Disease Control and Prevention, Suzhou, 215004, China.
Yu S; Department of Occupational Medicine and Environmental Toxicology, College of Public Health, Nantong University, Nantong, Jiangsu, 226019, China.
Wei H; Department of Occupational Medicine and Environmental Toxicology, College of Public Health, Nantong University, Nantong, Jiangsu, 226019, China.
Han Y; Department of Occupational Medicine and Environmental Toxicology, College of Public Health, Nantong University, Nantong, Jiangsu, 226019, China. Electronic address: hanyu@ntu.edu.cn.
Chen G; Department of Occupational Medicine and Environmental Toxicology, College of Public Health, Nantong University, Nantong, Jiangsu, 226019, China. Electronic address: chengang@ntu.edu.cn.

Toxicology ; 462: 152962, 2021 10.

Article em En | MEDLINE | ID: mdl-34560123

Assuntos

Trióxido de Arsênio/toxicidade; Chaperona BiP do Retículo Endoplasmático/genética; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Endorribonucleases/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Linhagem Celular; Humanos; MAP Quinase Quinase Quinase 5/metabolismo; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Regulação para Cima/efeitos dos fármacos; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

Arsenic trioxide (As(2)O(3)); Endoplasmic reticulum stress (ER stress); Glucose-regulated protein 78 (GRP78); Inositol-requiring enzyme 1α (IRE1α); p38 MAPK

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Endorribonucleases / Estresse do Retículo Endoplasmático / Trióxido de Arsênio / Chaperona BiP do Retículo Endoplasmático Limite: Humans Idioma: En Revista: Toxicology Ano de publicação: 2021 Tipo de documento: Article

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