Abnormal cortical responses elicited by audiovisual movies in patients with autism spectrum disorder with atypical sensory behavior: A magnetoencephalographic study.
Brain Dev
; 44(2): 81-94, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-34563417
ABSTRACT
BACKGROUND:
Atypical sensory behavior disrupts behavioral adaptation in children with autism spectrum disorder (ASD); however, neural correlates of sensory dysfunction using magnetoencephalography (MEG) remain unclear.METHOD:
We used MEG to measure the cortical activation elicited by visual (uni)/audiovisual (multisensory) movies in 46 children (7-14 years) were included in finalanalysis:
13 boys with atypical audiovisual behavior in ASD (AAV+), 10 without this condition, and 23 age-matched typically developing boys.RESULTS:
The AAV+ group demonstrated an increase in the cortical activation in the bilateral insula in response to unisensory movies and in the left occipital, right superior temporal sulcus (rSTS), and temporal regions to multisensory movies. These increased responses were correlated with severity of the sensory impairment. Increased theta-low gamma oscillations were observed in the rSTS in AAV+.CONCLUSION:
The findings suggest that AAV is attributed to atypical neural networks centered on the rSTS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Percepção
/
Percepção Auditiva
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Percepção Visual
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Córtex Cerebral
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Transtornos de Sensação
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Ondas Encefálicas
/
Transtorno do Espectro Autista
Limite:
Adolescent
/
Child
/
Humans
/
Male
Idioma:
En
Revista:
Brain Dev
Ano de publicação:
2022
Tipo de documento:
Article