Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species.

Cucarull, Blanca; Tutusaus, Anna; Hernáez-Alsina, Tania; García de Frutos, Pablo; Reig, María; Colell, Anna; Marí, Montserrat; Morales, Albert

Cucarull, Blanca; Tutusaus, Anna; Hernáez-Alsina, Tania; García de Frutos, Pablo; Reig, María; Colell, Anna; Marí, Montserrat; Morales, Albert.

Afiliação

Cucarull B; Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, 08036 Barcelona, Spain.
Tutusaus A; Departament de Biomedicina, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain.
Hernáez-Alsina T; Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, 08036 Barcelona, Spain.
García de Frutos P; Digestive Unit, Hospital San Pedro, Rioja Salud, 26006 Logroño, Spain.
Reig M; Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, 08036 Barcelona, Spain.
Colell A; Unidad Asociada (IMIM) IIBB-CSIC, CIBERCV, 08036 Barcelona, Spain.
Marí M; Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit, Hospital Clínic of Barcelona, University of Barcelona, CIBEREHD, IDIBAPS, 08036 Barcelona, Spain.
Morales A; Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, 08036 Barcelona, Spain.

Antioxidants (Basel) ; 10(9)2021 Aug 24.

Article em En | MEDLINE | ID: mdl-34572967

Palavras-chave

BCL-2; apoptosis; chemotherapy; glutathione; hepatocellular carcinoma; mitochondria; mitophagy; oxidative stress; superoxide; tumor spheroids

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Idioma: En Revista: Antioxidants (Basel) Ano de publicação: 2021 Tipo de documento: Article

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