Development and validation of a ferroptosis-related model for three digestive tract tumors based on a pan-cancer analysis.
Epigenomics
; 13(18): 1497-1514, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-34581636
ABSTRACT
Aims:
To develop a ferroptosis gene-based survival-predictor model for predicting the prognosis of patients with digestive tract tumors, a pan-caner analysis was performed. Materials &methods:
Based on unsupervised clustering and the expression levels of ferroptosis genes, patients with cancer were divided into two clusters. The least absolute shrinkage and selection operator method Cox regression analysis was used to establish the survival-predictor model.Results:
Based on the pan-cancer analysis, a 20 gene-based survival-predictor model for predicting survival rates was developed, which was validated in patients with hepatocellular carcinoma.Conclusion:
The survival-predictor model accurately predicted the prognosis of patients with digestive tract tumors.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Suscetibilidade a Doenças
/
Ferroptose
/
Neoplasias Gastrointestinais
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Epigenomics
Ano de publicação:
2021
Tipo de documento:
Article