Current strategies and technologies for finding drug targets of active components from traditional Chinese medicine.
Front Biosci (Landmark Ed)
; 26(9): 572-589, 2021 09 30.
Article
em En
| MEDLINE
| ID: mdl-34590468
ABSTRACT
Introduction:
The ambiguity of the drug target is one of the major factors restricting the development of traditional Chinese medicine (TCMs) and its bioactive constituents. The characteristics of "multiple components, multiple targets and multiple pathways" of TCMs make the research of drug targets extremely difficult. With the emergence of new theories, there are increasing technologies and strategies that can be used for the drug targets research of TCMs. In this paper, we summarize several techniques and methods applied to the study of TCM targets.Methods:
Through consulting a large number of literature, research and summary, and finally summarized the application direction of the technical method, advantages and limitations.Results:
The methods and techniques including computer aided drug design, network pharmacology, phage display, affinity fishing, drug affinity responsive target stability and cellular thermal shift assay were summarized, and their application directions, advantages and disadvantages were discussed. At the same time, a large number of application examples were given to provide reference for the research of TCM targets.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Medicina Tradicional Chinesa
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Front Biosci (Landmark Ed)
Ano de publicação:
2021
Tipo de documento:
Article