Adipose tissue immune cells in obesity, type 2 diabetes mellitus and cardiovascular diseases.
J Endocrinol
; 252(1): R1-R22, 2021 11 24.
Article
em En
| MEDLINE
| ID: mdl-34592714
ABSTRACT
Immune cells are an inseparable component of adipose tissue intimately involved in most of its functions. Physiologically, they regulate adipose tissue homeostasis, while in case of adipose tissue stress, immune cells are able to change their phenotype, enhance their count and subsequently contribute to the development and maintenance of local adipose tissue inflammation. Immune cells are an important source of inflammatory cytokines and other pro-inflammatory products that further influence not only surrounding tissues but via systemic circulation also the whole organism being thus one of the main factors responsible for the transition from simple obesity to associated metabolic and cardiovascular complications. The purpose of this review is to summarize current knowledge on different adipose tissue immune cell subsets and their role in the development of obesity, type 2 diabetes mellitus and cardiovascular diseases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Tecido Adiposo
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Diabetes Mellitus Tipo 2
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Sistema Imunitário
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Obesidade
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Endocrinol
Ano de publicação:
2021
Tipo de documento:
Article