Growth of Very Low Birth Weight Infants Who Received a Liquid Human Milk Fortifier: A Randomized, Controlled Multicenter Trial.
J Pediatr Gastroenterol Nutr
; 74(3): 424-430, 2022 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-34620759
ABSTRACT
OBJECTIVES:
To evaluate growth (weight, length, head circumference, and knee-heel length [KHL]) in very low birth weight (VLBW) infants (500-1500âg) who received human milk with a liquid fortifier (LHMF) with high protein and fatty acid content versus a traditional powder fortifier (PHMF) for 45âdays or until discharge.METHODS:
This was a multicenter, randomized, controlled trial. An intention-to-treat analysis was performed to determine adverse events and withdrawal causes. We also performed an efficacy analysis involving the infants who completed at least 2âweeks of study.RESULTS:
Of the 158 infants enrolled in the study, 146 completed at least 2âweeks, and 125 completed the entire study. The biodemographic characteristics were similar between groups, with no differences in increments of weight (22.9 vs 22.7âgâkg-1âday-1), length (1.03 vs 1.09âcm/week), head circumference (0.91 vs 0.90âcm/week), or KHL (3.6 vs 3.3âmm/week). The KHL increment was greater in infants weighing >1âkg receiving LHMF (3.7 vs 3.2âmm/week, Pâ=â0.027). Although there were no significant differences in serious adverse events, the incidence difference of the composite outcome death/necrotizing enterocolitis between groups warrants attention (1.3% with LHMF and 8.1% with PHMF).CONCLUSION:
There were no differences in the overall growth between VLBW infants receiving either fortifier.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Leite Humano
Tipo de estudo:
Clinical_trials
Limite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Ano de publicação:
2022
Tipo de documento:
Article