Strong acids induce amyloid fibril formation of ß<sub>2</sub>-microglobulin via an anion-binding mechanism.

Yamaguchi, Keiichi; Hasuo, Kenshiro; So, Masatomo; Ikenaka, Kensuke; Mochizuki, Hideki; Goto, Yuji

Strong acids induce amyloid fibril formation of ß₂-microglobulin via an anion-binding mechanism.

Yamaguchi, Keiichi; Hasuo, Kenshiro; So, Masatomo; Ikenaka, Kensuke; Mochizuki, Hideki; Goto, Yuji.

Afiliação

Yamaguchi K; Global Center for Medical Engineering and Informatics, Osaka University, Suita, Osaka, Japan; Institute for Protein Research, Osaka University, Suita, Osaka, Japan.
Hasuo K; Institute for Protein Research, Osaka University, Suita, Osaka, Japan.
So M; Institute for Protein Research, Osaka University, Suita, Osaka, Japan.
Ikenaka K; Department of Neurology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Mochizuki H; Department of Neurology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Goto Y; Global Center for Medical Engineering and Informatics, Osaka University, Suita, Osaka, Japan; Institute for Protein Research, Osaka University, Suita, Osaka, Japan. Electronic address: gtyj8126@protein.osaka-u.ac.jp.

J Biol Chem ; 297(5): 101286, 2021 11.

Article em En | MEDLINE | ID: mdl-34626645

Assuntos

Amiloide/química; Agregados Proteicos; Microglobulina beta-2/química; Ânions/química; Dicroísmo Circular; Humanos; Concentração de Íons de Hidrogênio; Cloreto de Sódio/química

Palavras-chave

amyloid fibrils; solubility; strong acid; supersaturation; ß(2)-microglobulin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microglobulina beta-2 / Agregados Proteicos / Amiloide Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article

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