More frequent olive oil intake is associated with reduced platelet activation in obesity.
Nutr Metab Cardiovasc Dis
; 31(12): 3322-3325, 2021 11 29.
Article
em En
| MEDLINE
| ID: mdl-34627691
ABSTRACT
BACKGROUND AND AIMS:
Obesity is an independent risk factor for atherosclerotic cardiovascular disease (CVD), and platelet hyperactivation in obesity may contribute to this association. Olive oil consumption is associated with lower cardiovascular disease (CVD) risk in the general population. However, little is known for individuals with obesity. We investigated whether olive oil intake is associated with platelet activation in obesity. METHODS ANDRESULTS:
We assessed platelet activation (surface P-selectin expression) with and without thrombin exposure and diet composition in 63 patients with severe obesity. Among 63 subjects with obesity, the mean age was 32.2 ± 8.0 years and BMI 44.1 ± 8.5 kg/m2. Olive oil intake was stratified into <1 time/week (n = 21), 1-3 times/week (n = 18), ≥4 times/week (n = 24). Strata did not differ by age, BMI or platelet count. Unstimulated P-selectin expression did not differ by olive oil consumption. Subjects with more frequent olive oil intake exhibited lower P-selectin expression on submaximal thrombin exposure.CONCLUSIONS:
More frequent olive oil intake is associated with reduced thrombin-induced platelet activation in obesity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Plaquetária
/
Azeite de Oliva
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Obesidade
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Nutr Metab Cardiovasc Dis
Ano de publicação:
2021
Tipo de documento:
Article