CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study.

Lorè, Nicola I; De Lorenzo, Rebecca; Rancoita, Paola M V; Cugnata, Federica; Agresti, Alessandra; Benedetti, Francesco; Bianchi, Marco E; Bonini, Chiara; Capobianco, Annalisa; Conte, Caterina; Corti, Angelo; Furlan, Roberto; Mantegani, Paola; Maugeri, Norma; Sciorati, Clara; Saliu, Fabio; Silvestri, Laura; Tresoldi, Cristina; Ciceri, Fabio; Rovere-Querini, Patrizia; Di Serio, Clelia; Cirillo, Daniela M; Manfredi, Angelo A

Lorè, Nicola I; De Lorenzo, Rebecca; Rancoita, Paola M V; Cugnata, Federica; Agresti, Alessandra; Benedetti, Francesco; Bianchi, Marco E; Bonini, Chiara; Capobianco, Annalisa; Conte, Caterina; Corti, Angelo; Furlan, Roberto; Mantegani, Paola; Maugeri, Norma; Sciorati, Clara; Saliu, Fabio; Silvestri, Laura; Tresoldi, Cristina; Ciceri, Fabio; Rovere-Querini, Patrizia; Di Serio, Clelia; Cirillo, Daniela M; Manfredi, Angelo A.

Afiliação

Lorè NI; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy. lore.nicolaivan@hsr.it.
De Lorenzo R; Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy. lore.nicolaivan@hsr.it.
Rancoita PMV; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy.
Cugnata F; Vita-Salute San Raffaele University, Milano, Italy.
Agresti A; University Centre for Statistics in the Biomedical Sciences (CUSSB), Vita-Salute San Raffaele University, Milan, Italy.
Benedetti F; University Centre for Statistics in the Biomedical Sciences (CUSSB), Vita-Salute San Raffaele University, Milan, Italy.
Bianchi ME; Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Bonini C; Vita-Salute San Raffaele University, Milano, Italy.
Capobianco A; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Conte C; Vita-Salute San Raffaele University, Milano, Italy.
Corti A; Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Furlan R; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy.
Mantegani P; Vita-Salute San Raffaele University, Milano, Italy.
Maugeri N; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy.
Sciorati C; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy.
Saliu F; Vita-Salute San Raffaele University, Milano, Italy.
Silvestri L; Vita-Salute San Raffaele University, Milano, Italy.
Tresoldi C; Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Ciceri F; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy.
Rovere-Querini P; Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Di Serio C; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy.
Cirillo DM; Vita-Salute San Raffaele University, Milano, Italy.
Manfredi AA; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy.

Mol Med ; 27(1): 129, 2021 10 18.

Article em En | MEDLINE | ID: mdl-34663207

Assuntos

COVID-19/diagnóstico; Quimiocina CXCL10/sangue; Doença da Artéria Coronariana/diagnóstico; Diabetes Mellitus/diagnóstico; Hipertensão/diagnóstico; Biomarcadores/sangue; Proteína C-Reativa/metabolismo; COVID-19/sangue; COVID-19/imunologia; COVID-19/mortalidade; Comorbidade; Doença da Artéria Coronariana/sangue; Doença da Artéria Coronariana/imunologia; Doença da Artéria Coronariana/mortalidade; Creatina/sangue; Diabetes Mellitus/sangue; Diabetes Mellitus/imunologia; Diabetes Mellitus/mortalidade; Feminino; Hospitalização; Humanos; Hipertensão/sangue; Hipertensão/imunologia; Hipertensão/mortalidade; Imunidade Humoral; Imunidade Inata; Inflamação; Unidades de Terapia Intensiva; L-Lactato Desidrogenase/sangue; Contagem de Leucócitos; Linfócitos/imunologia; Linfócitos/patologia; Masculino; Pessoa de Meia-Idade; Neutrófilos/imunologia; Neutrófilos/patologia; Prognóstico; Estudos Prospectivos; Estudos Retrospectivos; SARS-CoV-2; Índice de Gravidade de Doença; Análise de Sobrevida

Palavras-chave

Biomarkers; COVID-19 severity predictors; CXCL10; Decision tree

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD / 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Diabetes Mellitus / Quimiocina CXCL10 / COVID-19 / Hipertensão Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Mol Med Ano de publicação: 2021 Tipo de documento: Article

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