Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazoleâclove oil transferosomal nanoparticles.

Kammoun, Ahmed K; Khedr, Alaa; Hegazy, Maha A; Almalki, Ahmed J; Hosny, Khaled M; Abualsunun, Walaa A; Murshid, Samar S A; Bakhaidar, Rana B

Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazoleâclove oil transferosomal nanoparticles.

Kammoun, Ahmed K; Khedr, Alaa; Hegazy, Maha A; Almalki, Ahmed J; Hosny, Khaled M; Abualsunun, Walaa A; Murshid, Samar S A; Bakhaidar, Rana B.

Afiliação

Kammoun AK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Khedr A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Hegazy MA; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Almalki AJ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Hosny KM; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Abualsunun WA; Department of pharmaceutics and industrial pharmacy, Beni Suef University, Ben-Suef, Egypt.
Murshid SSA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Bakhaidar RB; Department of Natural products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

Drug Deliv ; 28(1): 2229-2240, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34668818

Assuntos

Antifúngicos/farmacologia; Aspergillus flavus/efeitos dos fármacos; Óleo de Cravo/farmacologia; Nanopartículas/química; Voriconazol/farmacologia; Animais; Antifúngicos/administração & dosagem; Antifúngicos/efeitos adversos; Antifúngicos/farmacocinética; Proteínas da Membrana Bacteriana Externa; Biomarcadores; Química Farmacêutica; Óleo de Cravo/administração & dosagem; Creatinina/sangue; Relação Dose-Resposta a Droga; Portadores de Fármacos/química; Liberação Controlada de Fármacos; Géis/química; Nefropatias/induzido quimicamente; Lipossomos/química; Seios Paranasais/metabolismo; Tamanho da Partícula; Coelhos; Reologia; Voriconazol/administração & dosagem; Voriconazol/efeitos adversos; Voriconazol/farmacocinética

Palavras-chave

Antifungal; boxâbehnken design; clove oil; rhinosinusitis; transferosomes; voriconazole

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus flavus / Óleo de Cravo / Nanopartículas / Voriconazol / Antifúngicos Limite: Animals Idioma: En Revista: Drug Deliv Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google