Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients.

Lay abstract Multiple sclerosis (MS) is a devastating disease that affects individuals at a young age and gradually worsens over their lifespan. Currently, treatment for MS is broad, meaning it treats the symptoms but not the cause of the disease. Treating symptoms means that patients may feel better, but their general quality of life is not normal. In addition, treating symptoms can lead to the underlying cause still being present, which can come back once treatment is stopped. What we are striving to do in this article is to better understand the cause. If we can do that, we can have targeted treatment that will get rid of the disease without the fear of it coming back and drastically improve quality of life and life span. Here, we have identified the complex nature of MS and made an effort to identify certain genes that are different in MS patients and present a way to better understand MS using advanced genome study methodologies.