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Biflavonoids from the twigs and leaves of Cephalotaxus oliveri Mast. and their α-glucosidase inhibitory activity.
Song, Min; Xiao, Tong; Wu, Qiu-Shuang; Kwok, Hang Fai; Chan, Ging; Lin, Li-Gen; Zhang, Xiao-Qi; Ye, Wen-Cai; He, Sheng-Jiang; Zhang, Qing-Wen.
Afiliação
  • Song M; State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, P.R. China.
  • Xiao T; State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, P.R. China.
  • Wu QS; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, P.R. China.
  • Kwok HF; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, P.R. China.
  • Chan G; State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, P.R. China.
  • Lin LG; State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, P.R. China.
  • Zhang XQ; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, P.R. China.
  • Ye WC; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, P.R. China.
  • He SJ; Guangzhou Egg Biotechnology, Co., Ltd, Guangzhou, P.R. China.
  • Zhang QW; State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, P.R. China.
Nat Prod Res ; 36(12): 3085-3094, 2022 Jun.
Article em En | MEDLINE | ID: mdl-34694166
ABSTRACT
Three new biflavonoids, umcephabiovins C - E (1 - 3), along with fourteen known compounds were isolated from the twigs and leaves of Cephalotaxus oliveri. Their structures and configurations were elucidated by UV, IR, NMR, ECD, and HR-ESI-MS spectra. Compounds 1 - 3 exhibited significant α-glucosidase inhibitory activity with IC50 values of 7.05 ± 2.66, 24.45 ± 4.73, and 1.84 ± 1.14 µM, respectively. Compound 11 showed moderate cytotoxicity against the BaF3/T315I cell line.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cephalotaxus / Biflavonoides Idioma: En Revista: Nat Prod Res Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cephalotaxus / Biflavonoides Idioma: En Revista: Nat Prod Res Ano de publicação: 2022 Tipo de documento: Article