Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates.
Sci Transl Med
; 13(617): eabg6463, 2021 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-34705521
ABSTRACT
Restoring dexterous hand control is critical for people with paralysis. Approaches based on surface or intramuscular stimulation provide limited finger control, generate insufficient force to recover functional movements, and require numerous electrodes. Here, we show that intrafascicular peripheral electrodes could produce functional grasps and sustained forces in three monkeys. We designed an intrafascicular implantable electrode targeting the motor fibers of the median and radial nerves. Our interface selectively and reliably activated extrinsic and intrinsic hand muscles, generating multiple functional grips, hand opening, and sustained contraction forces for up to 2 months. We extended those results to a behaving monkey with transient hand paralysis and used intracortical signals to control simple stimulation protocols that enabled this animal to perform a functional grasping task. Our findings show that just two intrafascicular electrodes can generate a rich portfolio of dexterous and functional hand movements with important implications for clinical applicability.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mãos
/
Movimento
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Revista:
Sci Transl Med
Ano de publicação:
2021
Tipo de documento:
Article