Design, synthesis and biological evaluation of novel evodiamine and rutaecarpine derivatives against phytopathogenic fungi.

Yang, Cheng-Jie; Li, Hai-Xin; Wang, Jing-Ru; Zhang, Zhi-Jun; Wu, Tian-Lin; Liu, Ying-Qian; Tang, Chen; Chu, Qing-Ru; Du, Sha-Sha; He, Ying-Hui

Yang, Cheng-Jie; Li, Hai-Xin; Wang, Jing-Ru; Zhang, Zhi-Jun; Wu, Tian-Lin; Liu, Ying-Qian; Tang, Chen; Chu, Qing-Ru; Du, Sha-Sha; He, Ying-Hui.

Afiliação

Yang CJ; School of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Li HX; School of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Wang JR; School of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Zhang ZJ; School of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Wu TL; School of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Liu YQ; School of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China; State Key Laboratory of Grassland Agro-ecosystems, Lanzhou University, Lanzhou, 730000, China. Electronic address: liuyqlab@163.com.
Tang C; School of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Chu QR; School of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Du SS; School of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
He YH; School of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.

Eur J Med Chem ; 227: 113937, 2022 Jan 05.

Article em En | MEDLINE | ID: mdl-34710744

Assuntos

Antifúngicos/farmacologia; Desenho de Fármacos; Alcaloides Indólicos/farmacologia; Quinazolinas/farmacologia; Antifúngicos/síntese química; Antifúngicos/química; Ascomicetos/efeitos dos fármacos; Botrytis/efeitos dos fármacos; Relação Dose-Resposta a Droga; Fusarium/efeitos dos fármacos; Alcaloides Indólicos/síntese química; Alcaloides Indólicos/química; Testes de Sensibilidade Microbiana; Estrutura Molecular; Quinazolinas/síntese química; Quinazolinas/química; Rhizoctonia/efeitos dos fármacos; Relação Estrutura-Atividade

Palavras-chave

Alkaloid; Antifungal activity; Evodiamine; Rutaecarpine; Sclerotinia sclerotiorum

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Desenho de Fármacos / Alcaloides Indólicos / Antifúngicos Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article

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