Placental mediated mechanisms of perinatal brain injury: Evolving inflammation and exosomes.
Exp Neurol
; 347: 113914, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-34752783
ABSTRACT
Pregnancy is an inflammatory process that is carefully regulated by the placenta via immunomodulation and cell-to-cell communication of maternal and fetal tissues. Exosomes, types of extracellular vesicles, facilitate the intercellular communication and traffic biologically modifying cargo within the maternal-placental-fetal axis in normal and pathologic pregnancies. Chorioamnionitis is characterized by inflammation of chorioamniotic membranes that produces systemic maternal and fetal inflammatory responses of cytokine dysregulation and has been associated with brain injury and neurodevelopmental disorders. This review focuses on how pathologic placental exosomes propagate acute and chronic inflammation leading to brain injury. The evidence reviewed here highlights the need to investigate exosomes from pathologic pregnancies and those with known brain injury to identify new diagnostics, biomarkers, and potential therapeutic targets.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Lesões Encefálicas
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Corioamnionite
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Mediadores da Inflamação
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Exossomos
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Exp Neurol
Ano de publicação:
2022
Tipo de documento:
Article