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The 2,3-epoxy naphthoquinol produced by endophyte Arthrinium marii M-211.
Sofian, Ferry Ferdiansyah; Suzuki, Takuma; Supratman, Unang; Harneti, Desi; Maharani, Rani; Salam, Supriatno; Abdullah, Fajar Fauzi; Yoshida, Jun; Ito, Yoshiaki; Koseki, Takuya; Shiono, Yoshihito.
Afiliação
  • Sofian FF; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan.
  • Suzuki T; The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate, Japan.
  • Supratman U; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan.
  • Harneti D; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Sumedang, Indonesia.
  • Maharani R; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Sumedang, Indonesia.
  • Salam S; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Sumedang, Indonesia.
  • Abdullah FF; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Sumedang, Indonesia.
  • Yoshida J; Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia.
  • Ito Y; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Garut, Garut, Indonesia.
  • Koseki T; Center for Liberal Arts and Sciences, Iwate Medical University, Yahaba, Iwate, Japan.
  • Shiono Y; Department of Biological Chemistry and Food Science, Faculty of Agriculture, Iwate University, Morioka, Iwate, Japan.
Nat Prod Res ; 37(7): 1060-1066, 2023 Apr.
Article em En | MEDLINE | ID: mdl-34753360
ABSTRACT
A novel 2,3-epoxy naphthoquinol, named (6R,7R,8R)-theissenone A (1), possessing an oxatricyclo[5.4.0.03,5]undeca-trien-2-one skeleton, together with two known compounds, (6S,7R,8R)-theissenone (2) and arthrinone (3), were produced by an endophytic fungus, Arthrinium marii M-211, which was isolated from mangrove plants. The structure of 1, including the absolute stereochemistry, was elucidated by analysis of nuclear magnetic resonance (NMR) and mass spectrometry (MS) data and time-dependent density functional theory (TDDFT) calculations of electronic circular dichroism (ECD) spectra. Additionally, the absolute structure of 2 was deduced as a diastereomer of 1 using ECD spectral data analysis. Compounds 1, 2 and 3 exhibited cytotoxic activity against the H4IIE rat hepatoma cells, with IC50 values of 67.5, 46.6 and 13.4 µM, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Endófitos Idioma: En Revista: Nat Prod Res Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Endófitos Idioma: En Revista: Nat Prod Res Ano de publicação: 2023 Tipo de documento: Article