Cancer cell-derived exosomal circUSP7 induces CD8<sup>+</sup> T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC.

Chen, Shi-Wei; Zhu, Shu-Qiang; Pei, Xu; Qiu, Bai-Quan; Xiong, Dian; Long, Xiang; Lin, Kun; Lu, Feng; Xu, Jian-Jun; Wu, Yong-Bing

Cancer cell-derived exosomal circUSP7 induces CD8⁺ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC.

Chen, Shi-Wei; Zhu, Shu-Qiang; Pei, Xu; Qiu, Bai-Quan; Xiong, Dian; Long, Xiang; Lin, Kun; Lu, Feng; Xu, Jian-Jun; Wu, Yong-Bing.

Afiliação

Chen SW; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, People's Republic of China.
Zhu SQ; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, People's Republic of China.
Pei X; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, People's Republic of China.
Qiu BQ; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, People's Republic of China.
Xiong D; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, People's Republic of China.
Long X; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, People's Republic of China.
Lin K; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, People's Republic of China.
Lu F; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, People's Republic of China.
Xu JJ; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, People's Republic of China.
Wu YB; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, People's Republic of China. wuyongbing789@163.com.

Mol Cancer ; 20(1): 144, 2021 11 09.

Article em En | MEDLINE | ID: mdl-34753486

Assuntos

Linfócitos T CD8-Positivos/metabolismo; Resistencia a Medicamentos Antineoplásicos/genética; MicroRNAs/genética; Proteína Tirosina Fosfatase não Receptora Tipo 11/genética; RNA Circular/genética; Peptidase 7 Específica de Ubiquitina/genética; Adulto; Idoso; Animais; Linfócitos T CD8-Positivos/imunologia; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Carcinoma Pulmonar de Células não Pequenas/patologia; Linhagem Celular Tumoral; Modelos Animais de Doenças; Exossomos/metabolismo; Feminino; Regulação Neoplásica da Expressão Gênica; Xenoenxertos; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Contagem de Linfócitos; Masculino; Camundongos; Pessoa de Meia-Idade; Metástase Neoplásica; Estadiamento de Neoplasias; Prognóstico; Interferência de RNA

Palavras-chave

Anti-PD1; Exosome; NSCLC; SHP2; circUSP7; miR-934

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Resistencia a Medicamentos Antineoplásicos / MicroRNAs / Proteína Tirosina Fosfatase não Receptora Tipo 11 / Peptidase 7 Específica de Ubiquitina / RNA Circular Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Cancer Ano de publicação: 2021 Tipo de documento: Article

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