Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses.

Bi, Xiaowen; Yan, Xintong; Jiang, Baolin; Liang, Juanjuan; Zhou, Jinyi; Lu, Shuai; Liu, Jie; Luo, Lan; Yin, Zhimin

Bi, Xiaowen; Yan, Xintong; Jiang, Baolin; Liang, Juanjuan; Zhou, Jinyi; Lu, Shuai; Liu, Jie; Luo, Lan; Yin, Zhimin.

Afiliação

Bi X; Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, China.
Yan X; Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, China.
Jiang B; Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, China.
Liang J; Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, China.
Zhou J; Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, China.
Lu S; Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, China.
Liu J; Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, China.
Luo L; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China. Electronic address: lanluo@nju.edu.cn.
Yin Z; Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, China. Electronic address: yinzhimin@njnu.edu.cn.

Toxicol Appl Pharmacol ; 433: 115778, 2021 12 15.

Article em En | MEDLINE | ID: mdl-34755645

Assuntos

Anti-Inflamatórios/farmacologia; Citocinas/metabolismo; Proteína HMGB1/metabolismo; Indoprofen/farmacologia; Mediadores da Inflamação/metabolismo; Pulmão/efeitos dos fármacos; Sepse/prevenção & controle; Animais; Inibidores de Ciclo-Oxigenase/farmacologia; Modelos Animais de Doenças; Humanos; Pulmão/imunologia; Pulmão/metabolismo; Macrófagos/efeitos dos fármacos; Macrófagos/imunologia; Macrófagos/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Monócitos/efeitos dos fármacos; Monócitos/imunologia; Monócitos/metabolismo; Células RAW 264.7; Receptor para Produtos Finais de Glicação Avançada/metabolismo; Sepse/imunologia; Sepse/metabolismo; Transdução de Sinais; Células THP-1; Receptor 2 Toll-Like/metabolismo; Receptor 4 Toll-Like/metabolismo

Palavras-chave

HMGB1; Indoprofen; Inflammatory response; LPS; Poly I:C; Sepsis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Indoprofen / Citocinas / Sepse / Mediadores da Inflamação / Proteína HMGB1 / Pulmão / Anti-Inflamatórios Limite: Animals / Humans / Male Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2021 Tipo de documento: Article

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