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A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein.
Littler, Dene R; Liu, Miaomiao; McAuley, Julie L; Lowery, Shea A; Illing, Patricia T; Gully, Benjamin S; Purcell, Anthony W; Chandrashekaran, Indu R; Perlman, Stanley; Purcell, Damian F J; Quinn, Ronald J; Rossjohn, Jamie.
Afiliação
  • Littler DR; Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. Electronic address: dene.littler@monash.edu.
  • Liu M; Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland, Australia.
  • McAuley JL; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
  • Lowery SA; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
  • Illing PT; Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Gully BS; Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Purcell AW; Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Chandrashekaran IR; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Perlman S; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA; Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
  • Purcell DFJ; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
  • Quinn RJ; Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland, Australia; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. Electronic address: r.quinn@griffith.edu.au.
  • Rossjohn J; Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom. Electronic address: jamie.ross
J Biol Chem ; 297(6): 101362, 2021 12.
Article em En | MEDLINE | ID: mdl-34756886
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Assunto principal: Antivirais / Replicação Viral / Proteínas de Ligação a RNA / Proteínas não Estruturais Virais / Diterpenos do Tipo Caurano / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Assunto principal: Antivirais / Replicação Viral / Proteínas de Ligação a RNA / Proteínas não Estruturais Virais / Diterpenos do Tipo Caurano / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article