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Thymodepressin-Unforeseen Immunosuppressor.
Deigin, Vladislav I; Vinogradova, Julia E; Vinogradov, Dmitry L; Krasilshchikova, Marina S; Ivanov, Vadim T.
Afiliação
  • Deigin VI; Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya st., 16/10, 117997 Moscow, Russia.
  • Vinogradova JE; Hematology Department, Sechenov First Moscow State Medical University, Russian MOH, Moscow 8-2 Trubetskaya str., 119991 Moscow, Russia.
  • Vinogradov DL; Hematology Department, Sechenov First Moscow State Medical University, Russian MOH, Moscow 8-2 Trubetskaya str., 119991 Moscow, Russia.
  • Krasilshchikova MS; Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya st., 16/10, 117997 Moscow, Russia.
  • Ivanov VT; Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya st., 16/10, 117997 Moscow, Russia.
Molecules ; 26(21)2021 Oct 29.
Article em En | MEDLINE | ID: mdl-34770959
The paper summarizes the available information concerning the biological properties and biomedical applications of Thymodepressin. This synthetic peptide drug displays pronounced immunoinhibitory activity across a wide range of conditions in vitro and in vivo. The history of its unforeseen discovery is briefly reviewed, and the current as well as potential expansion areas of medicinal practice are outlined. Additional experimental evidence is obtained, demonstrating several potential advantages of Thymodepressin over another actively used immunosuppressor drug, cyclosporin A.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Doença Enxerto-Hospedeiro / Imunossupressores Limite: Animals Idioma: En Revista: Molecules Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Doença Enxerto-Hospedeiro / Imunossupressores Limite: Animals Idioma: En Revista: Molecules Ano de publicação: 2021 Tipo de documento: Article