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Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2.
Liu, Ke; Zou, Rongfeng; Cui, Wenqiang; Li, Meiqing; Wang, Xueying; Dong, Junlin; Li, Hongchun; Li, Hongpei; Wang, Peihui; Shao, Ximing; Su, Wu; Chan, H C Stephen; Li, Hongchang; Yuan, Shuguang.
Afiliação
  • Liu K; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • Zou R; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • Cui W; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • Li M; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Wang X; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • Dong J; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Li H; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • Li H; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • Wang P; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • Shao X; College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
  • Su W; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
  • Chan HCS; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • Li H; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • Yuan S; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
ACS Pharmacol Transl Sci ; 3(6): 1361-1370, 2020 Dec 11.
Article em En | MEDLINE | ID: mdl-34778724
ABSTRACT
The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Pharmacol Transl Sci Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Pharmacol Transl Sci Ano de publicação: 2020 Tipo de documento: Article