Inhibition of the bromodomain and extra-terminal family of epigenetic regulators as a promising therapeutic approach for gastric cancer.

Kang, Sun Kyoung; Bae, Hyun Joo; Kwon, Woo Sun; Kim, Tae Soo; Kim, Kyoo Hyun; Park, Sejung; Yu, Seo Young; Hwang, Jihyun; Park, Juin; Chung, Hyun Cheol; Rha, Sun Young

Kang, Sun Kyoung; Bae, Hyun Joo; Kwon, Woo Sun; Kim, Tae Soo; Kim, Kyoo Hyun; Park, Sejung; Yu, Seo Young; Hwang, Jihyun; Park, Juin; Chung, Hyun Cheol; Rha, Sun Young.

Afiliação

Kang SK; Songdang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Bae HJ; MD Biolab Co., Ltd, Seoul, Republic of Korea.
Kwon WS; Songdang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim TS; Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim KH; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
Park S; Songdang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Yu SY; Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
Hwang J; Songdang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Park J; Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
Chung HC; Songdang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Rha SY; Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.

Cell Oncol (Dordr) ; 44(6): 1387-1403, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34791636

Assuntos

Epigênese Genética; Neoplasias Gástricas/tratamento farmacológico; Neoplasias Gástricas/genética; Fatores de Transcrição/antagonistas & inibidores; Animais; Biomarcadores Tumorais/metabolismo; Adesão Celular; Pontos de Checagem do Ciclo Celular; Proteínas de Ciclo Celular/metabolismo; Morte Celular; Linhagem Celular Tumoral; Proliferação de Células; Sinergismo Farmacológico; Epigênese Genética/efeitos dos fármacos; Feminino; Camundongos Endogâmicos BALB C; Camundongos Nus; Terapia de Alvo Molecular; Organoides/efeitos dos fármacos; Organoides/patologia; Paclitaxel/farmacologia; Paclitaxel/uso terapêutico; Fatores de Transcrição/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

BET inhibitor; BET protein; Combination therapy; Epigenetic regulation; GC organoid; Gastric cancer; Paclitaxel

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Fatores de Transcrição / Epigênese Genética Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Oncol (Dordr) Ano de publicação: 2021 Tipo de documento: Article

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