Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing.
Pathogens
; 10(11)2021 Nov 18.
Article
em En
| MEDLINE
| ID: mdl-34832660
ABSTRACT
Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on Acinetobacter baumannii and Pseudomonas aeruginosa to destroy factors that prevent serum-associated, complement-directed killing. The protease activity also enhances bacterial susceptibility to antibiotics in sera. These findings implicate a new paradigm where host protease activity on bacteria acts combinatorially with the host complement system and antibiotics to defeat bacterial pathogens.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Pathogens
Ano de publicação:
2021
Tipo de documento:
Article