Different circuitry dysfunction in drug-naive patients with juvenile myoclonic epilepsy and juvenile absence epilepsy.
Epilepsy Behav
; 125: 108443, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34837842
ABSTRACT
RATIONALE Juvenile myoclonic epilepsy (JME) and juvenile absence epilepsy (JAE) are generalized epileptic syndromes presenting in the same age range. To explore whether uneven network dysfunctions may underlie the two different phenotypes, we examined drug-naive patients with JME and JAE at the time of their earliest presentation. METHODS:
Patients were recruited based on typical JME (nâ¯=â¯23) or JAE (nâ¯=â¯18) presentation and compared with 16 age-matched healthy subjects (HS). We analyzed their awake EEG signals by Partial Directed Coherence and graph indexes.RESULTS:
Out-density and betweenness centrality values were different between groups. With respect to both JAE and HS, JME showed unbalanced out-density and out-strength in alpha and beta bands on central regions and reduced alpha out-strength from fronto-polar to occipital regions, correlating with photosensitivity. With respect to HS, JAE showed enhanced alpha out-density and out-strength on fronto-polar regions. In gamma band, JAE showed reduced Global/Local Efficiency and Clustering Coefficient with respect to HS, while JME showed more scattered values.CONCLUSIONS:
Our data suggest that regional network changes in alpha and beta bands underlie the different presentation distinguishing JME and JAE resulting in motor vs non-motor seizures characterizing these two syndromes. Conversely, impaired gamma-activity within the network seems to be a non-local marker of defective inhibition.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
/
Epilepsia Tipo Ausência
/
Epilepsia Mioclônica Juvenil
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Epilepsy Behav
Ano de publicação:
2021
Tipo de documento:
Article