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Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.
Kroth, Heiko; Oden, Felix; Serra, Andreia Monica; Molette, Jerome; Mueller, Andre; Berndt, Mathias; Capotosti, Francesca; Gabellieri, Emanuele; Schmitt-Willich, Heribert; Hickman, David; Pfeifer, Andrea; Dinkelborg, Ludger; Stephens, Andrew.
Afiliação
  • Kroth H; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland. Electronic address: heiko.kroth@acimmune.com.
  • Oden F; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Serra AM; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Molette J; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Mueller A; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Berndt M; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Capotosti F; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Gabellieri E; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Schmitt-Willich H; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Hickman D; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Pfeifer A; AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.
  • Dinkelborg L; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
  • Stephens A; Life Molecular Imaging GmbH, Tegeler Strasse 6-7, 13353 Berlin, Germany.
Bioorg Med Chem ; 52: 116528, 2021 12 15.
Article em En | MEDLINE | ID: mdl-34839158
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Proteínas tau / Compostos Radiofarmacêuticos / Doença de Alzheimer / Nitrogênio Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Proteínas tau / Compostos Radiofarmacêuticos / Doença de Alzheimer / Nitrogênio Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2021 Tipo de documento: Article