An overview of the production methods for core-shell microspheres for parenteral controlled drug delivery.
Eur J Pharm Biopharm
; 170: 24-42, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-34861359
ABSTRACT
Core-shell microspheres hold great promise as a drug delivery system because they offer several benefits over monolithic microspheres in terms of release kinetics, for instance a reduced initial burst release, the possibility of delayed (pulsatile) release, and the possibility of dual-drug release. Also, the encapsulation efficiency can significantly be improved. Various methods have proven to be successful in producing these core-shell microspheres, both the conventional bulk emulsion solvent evaporation method and methods in which the microspheres are produced drop by drop. The latter have become increasingly popular because they provide improved control over the particle characteristics. This review assesses various production methods for core-shell microspheres and summarizes the characteristics of formulations prepared by the different methods, with a focus on their release kinetics.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Microesferas
Idioma:
En
Revista:
Eur J Pharm Biopharm
Ano de publicação:
2022
Tipo de documento:
Article