Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing.

Wang, Yiquan; Lei, Ruipeng; Nourmohammad, Armita; Wu, Nicholas C

Wang, Yiquan; Lei, Ruipeng; Nourmohammad, Armita; Wu, Nicholas C.

Afiliação

Wang Y; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, United States.
Lei R; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, United States.
Nourmohammad A; Department of Physics, University of Washington, Seattle, United States.
Wu NC; Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.

Elife ; 102021 12 08.

Article em En | MEDLINE | ID: mdl-34878407

Assuntos

Antígenos Virais/imunologia; Evolução Molecular; Vírus da Influenza A Subtipo H3N2/imunologia; Neuraminidase/genética; Proteínas Virais/genética; Humanos; Influenza Humana/imunologia; Neuraminidase/imunologia; Proteínas Virais/imunologia

Palavras-chave

combinatorial mutagenesis; epistasis; evolution; evolutionary biology; infectious disease; influenza; influenza virus; microbiology; neuraminidase; next-generation sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Evolução Molecular / Vírus da Influenza A Subtipo H3N2 / Antígenos Virais / Neuraminidase Limite: Humans Idioma: En Revista: Elife Ano de publicação: 2021 Tipo de documento: Article

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