Insulin is expressed by enteroendocrine cells during human fetal development.
Nat Med
; 27(12): 2104-2107, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34887578
ABSTRACT
Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express high levels of insulin and other beta cell genes. Our findings highlight a potential extra-pancreatic source of beta cells and expose its molecular blueprint.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Enteroendócrinas
/
Desenvolvimento Fetal
/
Insulina
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Nat Med
Ano de publicação:
2021
Tipo de documento:
Article