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Long-Term Effects of Prematurity on Resting Ventilatory Response to Hypercapnia.
Manferdelli, Giorgio; Narang, Benjamin J; Poussel, Mathias; Osredkar, Damjan; Millet, Grégoire P; Debevec, Tadej.
Afiliação
  • Manferdelli G; Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
  • Narang BJ; Department of Automatics, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia.
  • Poussel M; Faculty of Sport, University of Ljubljana, Ljubljana, Slovenia.
  • Osredkar D; Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
  • Millet GP; Department of Pulmonary Function Testing and Exercise Physiology, CHRU de Nancy, Nancy, France.
  • Debevec T; Department of Pediatric Neurology, University Children's Hospital Ljubljana, Ljubljana, Slovenia.
High Alt Med Biol ; 22(4): 420-425, 2021 Dec.
Article em En | MEDLINE | ID: mdl-34905392
ABSTRACT
Manferdelli, Giorgio, Benjamin J. Narang, Mathias Poussel, Damjan Osredkar, Grégoire P. Millet, and Tadej Debevec. Long-term effects of prematurity on resting ventilatory response to hypercapnia. High Alt Med Biol. 22420-425, 2021.

Background:

This study investigated the resting ventilatory response to hypercapnia in prematurely born adults. Materials and

Methods:

Seventeen preterm and fourteen full-term adults were exposed to normoxic hypercapnia (two 5-minute periods at 3% and 6% carbon dioxide [CO2] interspersed by 5-minute in normoxia). Pulmonary ventilation ([Formula see text]) and end-tidal partial pressure of CO2 (Petco2) were measured continuously.

Results:

No difference in lung function was observed between preterm and full-term adults. Petco2 was lower in preterm than in full-term adults (p < 0.05) during normoxia. During exposure to 3% CO2, both [Formula see text] and Petco2 increased in a similar way in preterm and full-term adults. However, at the end of the 6% CO2 period, there was a significantly higher [Formula see text] in preterm compared with full-term adults (30.2 ± 7.5 vs. 23.7 ± 4.5 L/min, p < 0.0001), whereas no difference was observed for Petco2 (46.9 ± 2.1 vs. 50.6 ± 2.1 L/min, p = 0.99). Breath frequency was higher in preterm than in full-term adults (17.9 ± 4.0 vs. 12.8 ± 3.5 b/min, p < 0.01) during 6% CO2 exposure.

Conclusions:

Although data suggest that prematurity results in resting hypocapnia, the exact underlying mechanisms remain to be elucidated. Moreover, preterm adults seem to have increased chemosensitivity to hypercapnia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ventilação Pulmonar / Hipercapnia Limite: Adult / Humans / Newborn Idioma: En Revista: High Alt Med Biol Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ventilação Pulmonar / Hipercapnia Limite: Adult / Humans / Newborn Idioma: En Revista: High Alt Med Biol Ano de publicação: 2021 Tipo de documento: Article