Long-Term Effects of Prematurity on Resting Ventilatory Response to Hypercapnia.
High Alt Med Biol
; 22(4): 420-425, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34905392
ABSTRACT
Manferdelli, Giorgio, Benjamin J. Narang, Mathias Poussel, Damjan Osredkar, Grégoire P. Millet, and Tadej Debevec. Long-term effects of prematurity on resting ventilatory response to hypercapnia. High Alt Med Biol. 22420-425, 2021. Background:
This study investigated the resting ventilatory response to hypercapnia in prematurely born adults. Materials andMethods:
Seventeen preterm and fourteen full-term adults were exposed to normoxic hypercapnia (two 5-minute periods at 3% and 6% carbon dioxide [CO2] interspersed by 5-minute in normoxia). Pulmonary ventilation ([Formula see text]) and end-tidal partial pressure of CO2 (Petco2) were measured continuously.Results:
No difference in lung function was observed between preterm and full-term adults. Petco2 was lower in preterm than in full-term adults (p < 0.05) during normoxia. During exposure to 3% CO2, both [Formula see text] and Petco2 increased in a similar way in preterm and full-term adults. However, at the end of the 6% CO2 period, there was a significantly higher [Formula see text] in preterm compared with full-term adults (30.2 ± 7.5 vs. 23.7 ± 4.5 L/min, p < 0.0001), whereas no difference was observed for Petco2 (46.9 ± 2.1 vs. 50.6 ± 2.1 L/min, p = 0.99). Breath frequency was higher in preterm than in full-term adults (17.9 ± 4.0 vs. 12.8 ± 3.5 b/min, p < 0.01) during 6% CO2 exposure.Conclusions:
Although data suggest that prematurity results in resting hypocapnia, the exact underlying mechanisms remain to be elucidated. Moreover, preterm adults seem to have increased chemosensitivity to hypercapnia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ventilação Pulmonar
/
Hipercapnia
Limite:
Adult
/
Humans
/
Newborn
Idioma:
En
Revista:
High Alt Med Biol
Ano de publicação:
2021
Tipo de documento:
Article