[Effect of abnormal lipid metabolism on immune microenvironment in tumors].

ABSTRACT

The abnormality in lipid metabolism is an indication for malignant tumors and closely related to anti-tumor immune response. This abnormality is characterized by aberrant changes in metabolic signals, lipid transporters, metabolic substrates, metabolic enzymes and metabolites in lipid metabolism, which are mainly manifested as abnormal lipid accumulationin tumor cells. Aberrant lipid accumulation in the tumor microenvironment (TME) can affect both the phenotype and function of tumor infiltrating immune cells, which helps to construct an immunosuppressive tumor microenvironment and leads to immune escape of tumor cells. The anti-tumor immunotherapy can be improved by regulating the function of immune cells through targeting the abnormal molecules or pathways in lipid metabolism.