Your browser doesn't support javascript.
loading
Does GD2 synthase (GD2S) detect cancer stem cells in blood samples of breast carcinomas?
Mansoori, Maryam; Abdi Rad, Isa; Mirzaei, Alireza; Tam, Kevin J; Mohsen Hosseini, Seyed; Mahmodlu, Rahim; Mansouri, Fatemeh; Saeednejad Zanjani, Leili; Madjd, Zahra.
Afiliação
  • Mansoori M; Iran University of Medical Sciences, Oncopathology Research Center, Tehran, Iran.
  • Abdi Rad I; Iran University of Medical Sciences, Faculty of Advanced Technologies in Medicine, Department of Molecular Medicine, Tehran, Iran.
  • Mirzaei A; Urmia University of Medical Sciences, Cellular and Molecular Research Center, Urmia, Iran.
  • Tam KJ; Iran University of Medical Sciences, Shafa Orthopedic Hospital, Bone and Joint Reconstruction Research Center, Tehran, Iran.
  • Mohsen Hosseini S; University of British Columbia, Vancouver Prostate Centre, Department of Urologic Sciences, Vancouver, Canada.
  • Mahmodlu R; Omid specialty and subspecialty Hospital, Oncology and Radiotherapy Ward, Urmia, Iran.
  • Mansouri F; Urmia University of Medical Sciences, Faculty of Medicine, Imam Khomeini Hospital, Department of Surgery, Urmia, Iran.
  • Saeednejad Zanjani L; Urmia University of Medical Sciences, Faculty of Medicine, Department of Genetics and Immunology, Urmia, Iran.
  • Madjd Z; Iran University of Medical Sciences, Oncopathology Research Center, Tehran, Iran.
J Appl Biomed ; 19(4): 181-189, 2021 12.
Article em En | MEDLINE | ID: mdl-34907737
ABSTRACT

INTRODUCTION:

Cancer stem cells (CSCs) are a theorized subset of cells within the tumor that is thought to drive disease recurrence and metastatic spread. The aim of this study is to investigate mRNA and protein levels of ganglioside GD2 synthase (GD2S), in breast cancer (BC) patients.

METHODS:

65 PBMCs of preoperative BC patients without chemotherapy were compared to PBMCs after chemotherapy and controls.

RESULTS:

GD2S were significantly higher in BC patients after chemotherapy compared to pre-chemotherapy at both mRNA and protein. GD2S was higher in pre-chemotherapy blood samples compared to control samples.

CONCLUSIONS:

Higher expression of GD2S in BC samples compared to healthy control indicates the potential utility of GD2S as a marker of malignancy.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Neoplasias da Mama / N-Acetilgalactosaminiltransferases / Recidiva Local de Neoplasia Tipo de estudo: Diagnostic_studies Limite: Female / Humans Idioma: En Revista: J Appl Biomed Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Neoplasias da Mama / N-Acetilgalactosaminiltransferases / Recidiva Local de Neoplasia Tipo de estudo: Diagnostic_studies Limite: Female / Humans Idioma: En Revista: J Appl Biomed Ano de publicação: 2021 Tipo de documento: Article