Mitochondrial Localization of CB1 in Progesterone-producing Cells of Ovarian Interstitial Glands of Adult Mice.
J Histochem Cytochem
; 70(3): 251-257, 2022 03.
Article
em En
| MEDLINE
| ID: mdl-34915761
ABSTRACT
Localization of cannabinoid receptor type 1 (CB1) immunoreactivity on mitochondrial membranes, at least their outer membranes distinctly, was detected in progesterone-producing cells characterized by mitochondria having tubular cristae and aggregations of lipid droplets in ovarian interstitial glands in situ of adult mice. Both immunoreactive and immunonegative mitochondria were contained in one and the same cell. Considering that the synthesis of progesterone is processed in mitochondria, the mitochondrial localization of CB1 in the interstitial gland cells suggests the possibility that endocannabinoids modulate the synthetic process of progesterone in the cells through CB1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Progesterona
/
Receptor CB1 de Canabinoide
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Mitocôndrias
Limite:
Animals
Idioma:
En
Revista:
J Histochem Cytochem
Ano de publicação:
2022
Tipo de documento:
Article