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Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation.
Ring, Nadja Anneliese Ruth; Volpe, Maria Concetta; Stepisnik, Tomaz; Mamolo, Maria Grazia; Panov, Pance; Kocev, Dragi; Vodret, Simone; Fortuna, Sara; Calabretti, Antonella; Rehman, Michael; Colliva, Andrea; Marchesan, Pietro; Camparini, Luca; Marcuzzo, Thomas; Bussani, Rossana; Scarabellotto, Sara; Confalonieri, Marco; Pham, Tho X; Ligresti, Giovanni; Caporarello, Nunzia; Loffredo, Francesco S; Zampieri, Daniele; Dzeroski, Saso; Zacchigna, Serena.
Afiliação
  • Ring NAR; Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
  • Volpe MC; Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
  • Stepisnik T; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
  • Mamolo MG; Jozef Stefan Institute, Ljubljana, Slovenia; Jozef Stefan International Postgraduate School, Ljubljana, Slovenia.
  • Panov P; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.
  • Kocev D; Jozef Stefan Institute, Ljubljana, Slovenia; Jozef Stefan International Postgraduate School, Ljubljana, Slovenia.
  • Vodret S; Jozef Stefan Institute, Ljubljana, Slovenia; Jozef Stefan International Postgraduate School, Ljubljana, Slovenia.
  • Fortuna S; Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
  • Calabretti A; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.
  • Rehman M; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.
  • Colliva A; Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
  • Marchesan P; Yale School of Medicine Section of Nephrology, New Haven, CT, USA.
  • Camparini L; Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
  • Marcuzzo T; Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
  • Bussani R; Molecular Cardiology Unit, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
  • Scarabellotto S; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
  • Confalonieri M; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
  • Pham TX; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.
  • Ligresti G; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
  • Caporarello N; Arthritis Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
  • Loffredo FS; Arthritis Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
  • Zampieri D; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
  • Dzeroski S; Molecular Cardiology Unit, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
  • Zacchigna S; Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Cell Death Dis ; 13(1): 2, 2021 12 17.
Article em En | MEDLINE | ID: mdl-34916483
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Bleomicina / Ensaios de Seleção de Medicamentos Antitumorais / Fibrose Pulmonar Idiopática / Descoberta de Drogas / Ensaios de Triagem em Larga Escala / Miofibroblastos / Aprendizado de Máquina / Pneumopatias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Death Dis Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Bleomicina / Ensaios de Seleção de Medicamentos Antitumorais / Fibrose Pulmonar Idiopática / Descoberta de Drogas / Ensaios de Triagem em Larga Escala / Miofibroblastos / Aprendizado de Máquina / Pneumopatias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Death Dis Ano de publicação: 2021 Tipo de documento: Article