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Flexible Optogenetic Transducer Device for Remote Neuron Modulation Using Highly Upconversion-Efficient Dendrite-Like Gold Inverse Opaline Structure.
Chu, Chao-Yi; Wu, Pu-Wei; Chen, Jung-Chih; Tsou, Nien-Ti; Lin, You-Yi; Lo, Yu-Chun; Li, Ssu-Ju; Chang, Ching-Wen; Chen, Bo-Wei; Tsai, Chia-Lin; Chen, You-Yin; Liu, Ta-Chung; Chen, San-Yuan.
Afiliação
  • Chu CY; Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, ROC.
  • Wu PW; Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, ROC.
  • Chen JC; Department of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, ROC.
  • Tsou NT; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, ROC.
  • Lin YY; Catholic Mercy Hospital, Catholic Mercy Medical Foundation, Hsinchu, 303, Taiwan, ROC.
  • Lo YC; Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, ROC.
  • Li SJ; Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu, 300, Taiwan, ROC.
  • Chang CW; The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, No. 250 Wu-Xing St., Taipei, 110, Taiwan, ROC.
  • Chen BW; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, No.155, Sec. 2, Linong St., Taipei, 112, Taiwan, ROC.
  • Tsai CL; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, No.155, Sec. 2, Linong St., Taipei, 112, Taiwan, ROC.
  • Chen YY; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, No.155, Sec. 2, Linong St., Taipei, 112, Taiwan, ROC.
  • Liu TC; Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan, ROC.
  • Chen SY; The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, No. 250 Wu-Xing St., Taipei, 110, Taiwan, ROC.
Adv Healthc Mater ; 11(11): e2101310, 2022 06.
Article em En | MEDLINE | ID: mdl-34971080
ABSTRACT
A remote optogenetic device for analyzing freely moving animals has attracted extensive attention in optogenetic engineering. In particular, for peripheral nerve regions, a flexible device is needed to endure the continuous bending movements of these areas. Here, a remote optogenetic optical transducer device made from a gold inverse opaline skeleton grown with a dendrite-like gold nanostructure (D-GIOF) and chemically grafted with upconversion nanoparticles (UCNPs) is developed. This implantable D-GIOF-based transducer device can achieve synergistic interaction of the photonic crystal effect and localized surface plasmon resonance, resulting in considerable UCNP conversion efficiency with a negligible thermal effect under low-intensity 980 nm near-infrared (NIR) light excitation. Furthermore, the D-GIOF-based transducer device exhibits remarkable emission power retention (≈100%) under different bending states, indicating its potential for realizing peripheral nerve stimulation. Finally, the D-GIOF-based transducer device successfully stimulates neuronal activities of the sciatic nerve in mice. This study demonstrates the potential of the implantable device to promote remote NIR stimulation for modulation of neural activity in peripheral nerve regions and provides proof of concept for its in vivo application in optogenetic engineering.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Optogenética Limite: Animals Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Optogenética Limite: Animals Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2022 Tipo de documento: Article