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Novel insights into the consequences of obesity: a phenotype-wide Mendelian randomization study.
He, Chang; Zhang, Miaoran; Li, Jiuling; Wang, Yiqing; Chen, Lanlan; Qi, Baiyu; Wen, Jianping; Yang, Jianli; Lin, Sitong; Liu, Dianyuan; Dong, Ying; Wang, Liying; Wang, Qing; Chen, Peng.
Afiliação
  • He C; Department of Genetics, College of Basic Medical Sciences, Jilin University, Changchun, 130000, China.
  • Zhang M; Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, 130000, China.
  • Li J; Department of Pathology, College of Basic Medical Sciences, Jilin University, Changchun, 130000, China.
  • Wang Y; Department of Pathology, College of Basic Medical Sciences, Jilin University, Changchun, 130000, China.
  • Chen L; Department of Genetics, College of Basic Medical Sciences, Jilin University, Changchun, 130000, China.
  • Qi B; School of Clinical Medicine, Jilin University, Changchun, 130000, China.
  • Wen J; Department of Genetics, College of Basic Medical Sciences, Jilin University, Changchun, 130000, China.
  • Yang J; Department of Genetics, College of Basic Medical Sciences, Jilin University, Changchun, 130000, China.
  • Lin S; Department of Genetics, College of Basic Medical Sciences, Jilin University, Changchun, 130000, China.
  • Liu D; Department of Endocrinology, China-Japan Union Hospital, Jilin University, Changchun, 130000, China.
  • Dong Y; Department of Endocrinology, China-Japan Union Hospital, Jilin University, Changchun, 130000, China.
  • Wang L; Department of Radiotherapy, The Tumor Hospital of Jilin Province, Changchun, 130000, China.
  • Wang Q; Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, 130000, China. wlying@jlu.edu.cn.
  • Chen P; Department of Endocrinology, China-Japan Union Hospital, Jilin University, Changchun, 130000, China. wang_qing@jlu.edu.cn.
Eur J Hum Genet ; 30(5): 540-546, 2022 05.
Article em En | MEDLINE | ID: mdl-34974530
ABSTRACT
Obesity is thought to significantly impact the quality of life. In this study, we sought to evaluate the health consequences of obesity on the risk of a broad spectrum of human diseases. The causal effects of exposing to obesity on health outcomes were inferred using Mendelian randomization (MR) analyses using a fixed effects inverse-variance weighted model. The instrumental variables were SNPs associated with obesity as measured by body mass index (BMI) reported by GIANT consortium. The spectrum of outcome consisted of the phenotypes from published GWAS and the UK Biobank. The MR-Egger intercept test was applied to estimate horizontal pleiotropic effects, along with Cochran's Q test to assess heterogeneity among the causal effects of instrumental variables. Our MR results confirmed many putative disease risks due to obesity, such as diabetes, dyslipidemia, sleep disorder, gout, smoking behaviors, arthritis, myocardial infarction, and diabetes-related eye disease. The novel findings indicated that elevated red blood cell count was inferred as a mediator of BMI-induced type 2 diabetes in our bidirectional MR analysis. Intriguingly, the effects that higher BMI could decrease the risk of both skin and prostate cancers, reduce calorie intake, and increase the portion size warrant further studies. Our results shed light on a novel mechanism of the disease-causing roles of obesity.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise da Randomização Mendeliana / Obesidade Tipo de estudo: Clinical_trials / Prognostic_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Eur J Hum Genet Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise da Randomização Mendeliana / Obesidade Tipo de estudo: Clinical_trials / Prognostic_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Eur J Hum Genet Ano de publicação: 2022 Tipo de documento: Article