Hypoxia enhances motility and EMT through the Na<sup>+</sup>/H<sup>+</sup> exchanger NHE-1 in MDA-MB-231 breast cancer cells.

Takatani-Nakase, Tomoka; Matsui, Chihiro; Hosotani, Maiko; Omura, Mika; Takahashi, Koichi; Nakase, Ikuhiko

Hypoxia enhances motility and EMT through the Na⁺/H⁺ exchanger NHE-1 in MDA-MB-231 breast cancer cells.

Takatani-Nakase, Tomoka; Matsui, Chihiro; Hosotani, Maiko; Omura, Mika; Takahashi, Koichi; Nakase, Ikuhiko.

Afiliação

Takatani-Nakase T; Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo, 663-8179, Japan; Institute for Bioscience, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo, 663-8179, Japan. Electronic
Matsui C; Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo, 663-8179, Japan.
Hosotani M; Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo, 663-8179, Japan.
Omura M; Graduate School of Science, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8531, Japan.
Takahashi K; Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo, 663-8179, Japan.
Nakase I; Graduate School of Science, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8531, Japan; NanoSquare Research Institute, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka, 599-8570, Japan. Electronic address: i-nakase@21c.osakafu-u.ac.jp.

Exp Cell Res ; 412(1): 113006, 2022 03 01.

Article em En | MEDLINE | ID: mdl-34979106

Assuntos

Neoplasias da Mama/metabolismo; Trocador 1 de Sódio-Hidrogênio/metabolismo; Biomarcadores Tumorais/metabolismo; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Movimento Celular/fisiologia; Transição Epitelial-Mesenquimal/fisiologia; Feminino; Humanos; Modelos Biológicos; PPAR gama/agonistas; Transdução de Sinais/efeitos dos fármacos; Tiazolidinedionas/farmacologia; Hipóxia Tumoral/fisiologia; Microambiente Tumoral/fisiologia

Palavras-chave

Breast cancer; Hypoxic condition; Metastasis; NHE1; PPARÎ³1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Trocador 1 de Sódio-Hidrogênio Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Exp Cell Res Ano de publicação: 2022 Tipo de documento: Article

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