Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis.
PLoS One
; 17(1): e0262339, 2022.
Article
em En
| MEDLINE
| ID: mdl-34990478
ABSTRACT
BACKGROUND:
Neonatal sepsis is a serious condition. Recent clinical studies have indicated that microRNAs (miRNAs) are key players in the pathogenesis of sepsis, which could be used as biomarkers for this condition. PATIENTS ANDMETHODS:
A total of 90 neonates with sepsis and 90 healthy neonates were enrolled in this study. qRT-PCR was performed to measure the expression levels of serum miR-34a-5p and miR-199a-3p.RESULTS:
miR-34a-5p and miR-199a-3p serum levels were significantly reduced in neonates with sepsis compared with those in healthy neonates (P = 0.006 and P = 0.001, respectively). Significant correlations of miR-34a-5p and miR-199a-3p with each of TLC, RDW, RBS, and C-reactive protein (CRP) as well as SNAPII were observed, indicating their associations with the severity of neonatal sepsis.CONCLUSION:
miR-34a-5p and miR-199a-3p may be useful as novel biomarkers in neonatal sepsis and may provide a new direction for its treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
MicroRNAs
/
Sepse Neonatal
Limite:
Female
/
Humans
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Male
/
Newborn
Idioma:
En
Revista:
PLoS One
Ano de publicação:
2022
Tipo de documento:
Article