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Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency.
Das, Anirban; Sudhaman, Sumedha; Morgenstern, Daniel; Coblentz, Ailish; Chung, Jiil; Stone, Simone C; Alsafwani, Noor; Liu, Zhihui Amy; Karsaneh, Ola Abu Al; Soleimani, Shirin; Ladany, Hagay; Chen, David; Zatzman, Matthew; Cabric, Vanja; Nobre, Liana; Bianchi, Vanessa; Edwards, Melissa; Sambira Nahum, Lauren C; Ercan, Ayse B; Nabbi, Arash; Constantini, Shlomi; Dvir, Rina; Yalon-Oren, Michal; Campino, Gadi Abebe; Caspi, Shani; Larouche, Valerie; Reddy, Alyssa; Osborn, Michael; Mason, Gary; Lindhorst, Scott; Bronsema, Annika; Magimairajan, Vanan; Opocher, Enrico; De Mola, Rebecca Loret; Sabel, Magnus; Frojd, Charlotta; Sumerauer, David; Samuel, David; Cole, Kristina; Chiaravalli, Stefano; Massimino, Maura; Tomboc, Patrick; Ziegler, David S; George, Ben; Van Damme, An; Hijiya, Nobuko; Gass, David; McGee, Rose B; Mordechai, Oz; Bowers, Daniel C.
Afiliação
  • Das A; Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Sudhaman S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Morgenstern D; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Coblentz A; Department of Paediatric Haematology/ Oncology, Tata Medical Centre, Kolkata, India.
  • Chung J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Stone SC; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Alsafwani N; Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Liu ZA; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
  • Karsaneh OAA; Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Soleimani S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Ladany H; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Chen D; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Zatzman M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Cabric V; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Nobre L; Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University (IAU), Dammam, Saudi Arabia.
  • Bianchi V; Department of Biostatistics, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Edwards M; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
  • Sambira Nahum LC; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Ercan AB; Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
  • Nabbi A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Constantini S; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Dvir R; Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Tel-Aviv, Israel.
  • Yalon-Oren M; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Campino GA; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Caspi S; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Larouche V; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
  • Reddy A; Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Osborn M; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Mason G; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Lindhorst S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Bronsema A; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Magimairajan V; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Opocher E; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • De Mola RL; Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Sabel M; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Frojd C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Sumerauer D; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Samuel D; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Cole K; Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv, Israel.
  • Chiaravalli S; Department of Pediatric Hematology-Oncology, Tel-Aviv Sourasky Medical Centre, Tel-Aviv, Israel.
  • Massimino M; Department of Pediatric Hematology-Oncology, Sheba Medical Centre, Ramat Gan, Israel.
  • Tomboc P; Department of Pediatric Hematology-Oncology, Sheba Medical Centre, Ramat Gan, Israel.
  • Ziegler DS; Department of Pediatric Hematology-Oncology, Sheba Medical Centre, Ramat Gan, Israel.
  • George B; Department of Paediatric Haematology/Oncology, Centre Hospitalier de Quebec-Universite Laval, Quebec City, Quebec, Canada.
  • Van Damme A; Departments of Neurology and Pediatrics, University of California, San Francisco, CA, USA.
  • Hijiya N; Women's and Children's Hospital, North Adelaide, South Australia, Australia.
  • Gass D; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • McGee RB; Neuro-Oncology, Department of Neurosurgery, and Department of Medicine, Division of Hematology/Medical Oncology, Medical University of South Carolina, Charleston, SC, USA.
  • Mordechai O; Department of Paediatric Haematology and Oncology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Bowers DC; Department of Paediatric Haematology-Oncology, Cancer Care Manitoba, Research Institute in Oncology and Haematology, University of Manitoba, Winnipeg, Manitoba, Canada.
Nat Med ; 28(1): 125-135, 2022 01.
Article em En | MEDLINE | ID: mdl-34992263
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Mutação em Linhagem Germinativa / Reparo do DNA / Replicação do DNA / Antígeno B7-H1 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Nat Med Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Mutação em Linhagem Germinativa / Reparo do DNA / Replicação do DNA / Antígeno B7-H1 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Nat Med Ano de publicação: 2022 Tipo de documento: Article