Perylenequinone derivatives from the endolichenic fungus Phialocephala fortinii.
Nat Prod Res
; 37(9): 1527-1535, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-35007177
ABSTRACT
Five undescribed perylenequinone derivatives (PQDs) phialocephalarins H - L (1 - 5), together with two known PQDs phialocephalarins A - B (6, 7) and one known spirobisnaphthalene palmarumycin P3 (8) were isolated from the endolichenic fungus Phialocephala fortinii. Their structures were elucidated on the basis of NMR and HRESIMS data as well as electronic circular dichroism (ECD) calculations. Compounds 1, 2, 4, and 6 - 8 were evaluated for cytotoxic activities against NCI-H460, NCI-H446, PC3, and EC109 cell lines. The results showed that compounds 1, 2, 6, and 8 showed cytotoxic activities against EC109 cells with IC50 values ranging from 24.5 to 33.3 µM.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Antineoplásicos
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2023
Tipo de documento:
Article