The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors.
Molecules
; 27(1)2022 Jan 02.
Article
em En
| MEDLINE
| ID: mdl-35011505
ABSTRACT
Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan. Under inflammatory conditions, however, there is an upregulation of the KP enzymes, particularly kynurenine 3-monooxygenase (KMO). KMO has garnered much attention due to its production of toxic metabolites that have been implicated in many diseases and disorders. With many of these illnesses having an inadequate or modest treatment, there exists a need to develop KMO inhibitors that reduce the production of these toxic metabolites. Though prior efforts to find an appropriate KMO inhibitor were unpromising, the development of a KMO crystal structure has provided the opportunity for a rational structure-based design in the development of inhibitors. Therefore, the purpose of this review is to describe the kynurenine pathway, the kynurenine 3-monooxygenase enzyme, and KMO inhibitors and their potential candidacy for clinical use.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
/
Regulação Enzimológica da Expressão Gênica
/
Inibidores Enzimáticos
/
Quinurenina 3-Mono-Oxigenase
/
Cinurenina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Molecules
Ano de publicação:
2022
Tipo de documento:
Article