Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate M1 Microglial Activation in Brain Injury of Mice With Subarachnoid Hemorrhage via microRNA-140-5p Delivery.

Qian, Yu; Li, Qiaoyu; Chen, Lulu; Sun, Jinyu; Cao, Kan; Mei, Zhaojun; Lu, Xinyu

Qian, Yu; Li, Qiaoyu; Chen, Lulu; Sun, Jinyu; Cao, Kan; Mei, Zhaojun; Lu, Xinyu.

Afiliação

Qian Y; Department of Neurosurgery, the Affiliated People's Hospital of Jiangsu University, Zhenjiang, P.R. China.
Li Q; Department of Neurosurgery, Nanjing Medical University Affiliated Zhenjiang First People's Hospital, Zhenjiang, P.R. China.
Chen L; Department of Neurosurgery, the Affiliated People's Hospital of Jiangsu University, Zhenjiang, P.R. China.
Sun J; Department of Neurosurgery, Nanjing Medical University Affiliated Zhenjiang First People's Hospital, Zhenjiang, P.R. China.
Cao K; Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, P.R. China.
Mei Z; The First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.
Lu X; Department of Neurosurgery, the Affiliated People's Hospital of Jiangsu University, Zhenjiang, P.R. China.

Int J Neuropsychopharmacol ; 25(4): 328-338, 2022 04 19.

Article em En | MEDLINE | ID: mdl-35015859

Assuntos

Lesões Encefálicas; Vesículas Extracelulares; Células-Tronco Mesenquimais; MicroRNAs; Hemorragia Subaracnóidea; Animais; Lesões Encefálicas/metabolismo; Vesículas Extracelulares/metabolismo; Células-Tronco Mesenquimais/metabolismo; Camundongos; MicroRNAs/genética; MicroRNAs/metabolismo; Microglia/metabolismo; Hemorragia Subaracnóidea/metabolismo; Hemorragia Subaracnóidea/terapia

Palavras-chave

ALK5; M1 microglia activation; NOX2; brain injury; extracellular vesicles; mesenchymal stem cells; microRNA-140-5p; subarachnoid hemorrhage

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Subaracnóidea / Lesões Encefálicas / MicroRNAs / Células-Tronco Mesenquimais / Vesículas Extracelulares Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Neuropsychopharmacol Ano de publicação: 2022 Tipo de documento: Article

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