Bile acid homeostasis in female mice deficient in <i>Cyp7a1</i> and <i>Cyp27a1</i>.

Rizzolo, Daniel; Kong, Bo; Taylor, Rulaiha E; Brinker, Anita; Goedken, Michael; Buckley, Brian; Guo, Grace L

Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1.

Rizzolo, Daniel; Kong, Bo; Taylor, Rulaiha E; Brinker, Anita; Goedken, Michael; Buckley, Brian; Guo, Grace L.

Afiliação

Rizzolo D; Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Kong B; Environmental and Occupational Health Institute, Rutgers University, Piscataway, NJ 08854, USA.
Taylor RE; Rutgers Center of Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA.
Brinker A; Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Goedken M; Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Buckley B; Environmental and Occupational Health Institute, Rutgers University, Piscataway, NJ 08854, USA.
Guo GL; Office of Research and Economic Development, Research Pathology Services, Rutgers University, Piscataway, NJ 08854, USA.

Acta Pharm Sin B ; 11(12): 3847-3856, 2021 Dec.

Article em En | MEDLINE | ID: mdl-35024311

Palavras-chave

ALP, alkaline phosphatase; ALT, alanine aminotransferase; ASBT, apical sodium-dependent BA transporter; AST, aspartate transaminase; BA, bile acid; BSEP, bile salt export pump; Bile acids; CA, cholic acid; CDCA, chenodeoxycholic acid; CYP27A1; CYP27A1, sterol 27-hydroxylase; CYP2C70, cytochrome P450 2C70; CYP7A1; CYP7A1, cholesterol 7α-hydroxylase; CYP7B1, 25-hydroxycholesterol 7-alpha-hydroxylase; CYP8B1, sterol 12α-hydroxylase; DCA, deoxycholic acid; DKO, double knockout; FXR, farnesoid X receptor; Farnesoid X receptor; Female; Fibroblast growth factor 15; IBABP, intestinal BA-binding protein; LCA, lithocholic acid; NTCP, sodium taurocholate cotransporting polypeptide; OATP, organic anion transporters; OSTα/ß, organic solute transporters alpha and beta; WT, wild type; ßMCA, beta muricholic acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2021 Tipo de documento: Article

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