The structures of two polysaccharides from Angelica sinensis and their effects on hepatic insulin resistance through blocking RAGE.

Liu, Wenjuan; Li, Zezhi; Feng, Caixia; Hu, Shengwei; Yang, Xin; Xiao, Kaimin; Nong, Qiuna; Xiao, Qianhan; Wu, Kehan; Li, Xiao-Qiang; Cao, Wei

Liu, Wenjuan; Li, Zezhi; Feng, Caixia; Hu, Shengwei; Yang, Xin; Xiao, Kaimin; Nong, Qiuna; Xiao, Qianhan; Wu, Kehan; Li, Xiao-Qiang; Cao, Wei.

Afiliação

Liu W; Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Li Z; Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Feng C; Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Hu S; Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Yang X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Xiao K; Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Nong Q; Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Xiao Q; Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Wu K; Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Li XQ; Department of Pharmacology and Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Cao W; Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China; Department of Pharmacology and Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditi

Carbohydr Polym ; 280: 119001, 2022 Mar 15.

Article em En | MEDLINE | ID: mdl-35027136

Assuntos

Angelica sinensis/química; Resistência à Insulina; Fígado/metabolismo; Polissacarídeos/química; Polissacarídeos/farmacologia; Receptor para Produtos Finais de Glicação Avançada/metabolismo; Animais; Sequência de Carboidratos; Diabetes Mellitus Tipo 2/metabolismo; Glucose/metabolismo; Células Hep G2; Humanos; Hipoglicemiantes/química; Hipoglicemiantes/farmacologia; Insulina/metabolismo; Proteínas Substratos do Receptor de Insulina/metabolismo; Janus Quinases/metabolismo; Fígado/efeitos dos fármacos; Sistema de Sinalização das MAP Quinases; Masculino; Polissacarídeos/metabolismo; Ratos; Ratos Sprague-Dawley; Receptor para Produtos Finais de Glicação Avançada/antagonistas & inibidores; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

Angelica sinensis; Insulin resistance; Polysaccharide; Structure; Type 2 diabetes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Resistência à Insulina / Angelica sinensis / Receptor para Produtos Finais de Glicação Avançada / Fígado Limite: Animals / Humans / Male Idioma: En Revista: Carbohydr Polym Ano de publicação: 2022 Tipo de documento: Article

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