The essential anti-angiogenic strategies in cartilage engineering and osteoarthritic cartilage repair.
Cell Mol Life Sci
; 79(1): 71, 2022 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-35029764
ABSTRACT
In the cartilage matrix, complex interactions occur between angiogenic and anti-angiogenic components, growth factors, and environmental stressors to maintain a proper cartilage phenotype that allows for effective load bearing and force distribution. However, as seen in both degenerative disease and tissue engineering, cartilage can lose its vascular resistance. This vascularization then leads to matrix breakdown, chondrocyte apoptosis, and ossification. Research has shown that articular cartilage inflammation leads to compromised joint function and decreased clinical potential for regeneration. Unfortunately, few articles comprehensively summarize what we have learned from previous investigations. In this review, we summarize our current understanding of the factors that stabilize chondrocytes to prevent terminal differentiation and applications of these factors to rescue the cartilage phenotype during cartilage engineering and osteoarthritis treatment. Inhibiting vascularization will allow for enhanced phenotypic stability so that we are able to develop more stable implants for cartilage repair and regeneration.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
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Cartilagem
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Inibidores da Angiogênese
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Engenharia Tecidual
Limite:
Animals
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Humans
Idioma:
En
Revista:
Cell Mol Life Sci
Ano de publicação:
2022
Tipo de documento:
Article