Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization.

Li, SiChan; Wu, SanLan; Gong, WeiJing; Cao, Peng; Chen, Xin; Liu, Wanyu; Xiang, Liping; Wang, Yang; Huang, JianGeng

Li, SiChan; Wu, SanLan; Gong, WeiJing; Cao, Peng; Chen, Xin; Liu, Wanyu; Xiang, Liping; Wang, Yang; Huang, JianGeng.

Afiliação

Li S; Department of Clinical Pharmacy, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wu S; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gong W; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan, China.
Cao P; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen X; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan, China.
Liu W; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiang L; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan, China.
Wang Y; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huang J; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Front Pharmacol ; 12: 730826, 2021.

Article em En | MEDLINE | ID: mdl-35046798

Palavras-chave

CYP2C19; genetic polymorphism; population pharmacokinetics; voriconazole; voriconazole N-oxide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Pharmacol Ano de publicação: 2021 Tipo de documento: Article

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